Dr. Levy has a good analysis here, coupled with the Mass. experiment. (I didn’t know costs went up)!
Top Pain Scientist Fabricated Data in Studies, Hospital Says – WSJ.com
A prominent Massachusetts anesthesiologist allegedly fabricated 21 medical studies that claimed to show benefits from painkillers like Vioxx and Celebrex, according to the hospital where he worked.
Baystate Medical Center, Springfield, Mass., said that its former chief of acute pain, Scott S. Reuben, had faked data used in the studies, which were published in several anesthesiology journals between 1996 and 2008.
Holy moly. Bad evidence is worse than none.
A guy who really reads the literature (Joe Lex from Temple in Philly) tells me that the major impediment to EBM is that most of the literature is crap. Here’s some verification of that.